The influence of lignin modification on drug release and pH-dependent releasing behavior\nof oral solid dosage forms was investigated using three different formulations. The first formulation\ncontains microcrystalline cellulose (MCC 101) as the excipient and paracetamol as the active\npharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101\nas the excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin,\nMCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin\ncan be readily chemically modified due to the existence of different functional groups in its structure.\nThe focus of this investigation is on lignin carboxylation and its influence on paracetamol control\nrelease behavior at varying pH. Results suggest that carboxylated lignin tablets had the highest drug\nrelease, which is linked to their faster disintegration and lower tablet hardness.
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